SPE technology effectively removes matrix interferences from complex samples, improving sample purity and detection sensitivity while extending the lifetime of chromatographic systems and cartridges.
Common SPE sorbents include normal phase, reversed phase, ion exchange, and mixed-mode materials. The choice of sorbent depends on the properties of the target analytes and the interfering substances.
The primary purpose of SPE is to separate target compounds from major interferences using SPE cartridges, thereby achieving sample purification. Selecting the right SPE sorbent requires understanding the differences between target analytes and interferences. While no single approach can cover all possible matrices and analytes, applying this principle usually leads to optimal results.
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